North Carolina State University (NCSU) located in Raleigh, North Carolina is a major academic institution in the USA with broad expertise in science and engineering. Nanotechnology is a key component of research at NCSU and spans multiple colleges within the university, including the College of Chemical and Biomolecular Engineering and the College of Sciences. The NCSU Toxicology Graduate Program has played a major role in research related to the human health effects of engineered nanomaterials, including carbon nanotubes. Dr. James Bonner leads a research group that investigates mechanisms of lung disease in mice caused by exposure to nanomaterials. The Bonner Lab is best known for discoveries on the mechanisms of pulmonary fibrogenesis caused by toxicants, including engineered nanomaterials, and progress in developing animal models of disease susceptibility to nanomaterials. The NCSU research component of ICONS is funded by the U.S. National Science Foundation (NSF).